The St. Francis River is a tributary of the Mississippi River, about 426 miles long, in southeastern Missouri and northeastern Arkansas in the United States. The river drains a mostly rural area and forms part of the Missouri-Arkansas state line along the western side of the Missouri Bootheel.
Country: United States
State: Missouri, Arkansas
Region: Ozark Plateau, Mississippi Alluvial Plain
District: St. Francois Mountains, Crowleys Ridge
Cities: Farmington, Missouri, Fisk, Missouri, Lake City, Arkansas, Marked Tree, Arkansas
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