The Guardians were knocking on the door all night. The home team in red had every opportunity to break the door down in their eventual 10-5 victory over the Orioles. Inning after inning, Cleveland just couldn't deliver with runners in scoring position.

Baltimore’s Ryan O’Hearn, with two out in the third, sent a grounder to third baseman Jose Ramirez. Santana tried to scoop Ramirez’s throw, but it hit his glove and fell out. Former Guardian Ramon Laureano, the next batter, added an extra sting to the error by homering off Tanner Bibee for a 5-3 lead.

On July 21, 2025, the Cleveland Guardians defeated the Baltimore Orioles 10-5 at Progressive Field, improving their record to 49-50 and holding second place in the AL Central. The Orioles, now 44-55,

Jose Ramirez hit a three-run homer and Bo Naylor and Kyle Manzardo had solo shots as the Cleveland Guardians beat the visiting Baltimore Orioles 10-5 in their series opener Monday night.