The Tennessee Lottery offers several draw games for those aiming to win big. Here’s a look at April 21, 2025, results for each game: 04-33-45-46-51, Powerball: 25, Power Play: 3 Start the day smarter.

The Powerball jackpot rose to $139 million ahead of Monday's drawing. Check here for the winning numbers for April 21, 2025.

The winning numbers in Saturday evening’s drawing of the "Powerball" game were: 07-25-37-39-63, Powerball: 1 (seven, twenty-five, thirty-seven, thirty-nine, sixty-three, Powerball: one, Power Play: three)