In a new review, experts call for the removal of diphenhydramine from over-the-counter and prescription markets in the United ...

This risk was even higher in children aged 6 to 24 months who were prescribed first-generation antihistamines (aOR, 1.49) versus children aged 25 months to 6 years (aOR, 1.11).

A new paper argues that Benadryl should be phased out due to its side effects and potential for harm. Newer antihistamines, like Claritin and Zyrtec, are safer and cause less drowsiness, the paper ...

Stratified analyses showed similar results, especially among children six months to two years of age who received first-generation antihistamine prescriptions having a risk of seizure (AOR, 1.5 ...

A Korean study identified a 22% increased risk for seizure among young children who were prescribed first-generation antihistamines, according to findings published in JAMA Network Open ...

Older antihistamines, known as first-generation antihistamines, such as diphenhydramine (ZzzQuil) and doxylamine (Unisom) cross into the brain and block histamine receptors there, whereas second ...

Second-generation antihistamines are also less likely to make you drowsy, a major complaint with first-generation antihistamines. “Allergists often recommend these over first-generation antihistamines ...

A first generation antihistamine, called cinnarizine, is known to improve blood flow to the inner ear, which can reduce feelings of nausea and dizziness caused by travel sickness.

TOPLINE: First-generation antihistamines are linked to a 22% higher risk for seizures in children, new research shows. The risk appears to be most pronounced in children aged 6-24 months.

About The Study: Prescriptions for first-generation antihistamines were associated with a 22.0% higher seizure risk in children, especially in those ages 6 to 24 months in this cohort study.