Tight junctions (blue dots) between cells are connected areas of the plasma membrane that stitch cells together. Adherens junctions (red dots) join the actin filaments of neighboring cells together.

Actin cross-linking proteins are responsible for organizing actin fibers into the scaffolding that allows a cell to move, change shape, and do much more. For example, in this video, you can see that ...

In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is commonly known to be responsible for protein trafficking and secretion. In ...

Protein complexes within each cell further connect the transmembrane adhesive proteins to the cytoskeleton. In particular, adaptor complexes bind adherens junctions to cytoskeletal actin ...

“An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis,” eLife, 3:e00829, 2014. For decades, scientists observed clathrin-mediated endocytosis (CME)—the process ...

In all eukaryotic cells, actin protein assembles to form a network of thin filaments that spread throughout the cell. The actin filaments give the cell its structure, enable the cell to move, and ...

Beads of different radii moved differently within the nuclei—larger particles got stuck more often than smaller ones—which suggested that they were traveling through a network of actin ... an ...

Discovery of new F-actin-binding proteins for cell-cell and cell-matrix junctions: Two new F-actin-binding proteins (neurabin and nexilin) were found. Neurabin controls the actin cytoskeleton ...

We want to know the mechanistic details of how our cells work, move, and change their shape ... of 2020 to continue PhD studies and my interests lie in actin regulation at epithelial junctions. In ...

The group of Pekka Lappalainen at the Institute of Biotechnology uses a wide range of cell biology, light microscopy imaging, biochemistry and genetic methods to elucidate how the actin cytoskeleton ...