These observations led to the discovery of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), the two key enzymes of fatty acid synthesis. His laboratory was the first to identify these ...

The two megasynthases catalyze fatty acid synthesis by the classical mechanism (Fig. 1a), but differ in three of their domains (Fig. 1b,c) because they have different products. The mammalian FAS ...

1. It is evident, therefore, that an excessive lipid burden placed on the muscle cell in the form of nonesterified or VLDL-borne fatty acids can cause increased LCACoA levels and, secondarily ...