Oncotarget recently published "PD-1/PD-L1 expression in anal squamous intraepithelial lesions" which reported that the presence and distribution of CD8 lymphocytes and the presence of PD-1 ...

Source Reference: Palefsky J, et al "Treatment of anal high-grade squamous intraepithelial lesions to prevent anal cancer" N Engl J Med 2022; DOI: 10.1056/NEJMoa2201048.

Host genomic abnormalities may determine the natural history of cervical squamous intraepithelial lesions (SILs). We undertook comparative genomic hybridisation analysis of epithelium carefully ...

Reference Palefsky JM, Lee JY, Jay N, et al. Treatment of anal high-grade squamous intraepithelial lesions to prevent anal cancer. N Engl J Med. Published online June 15, 2022.

Background: Men who have sex with men (MSM) are at increased risk for high-grade squamous intraepithelial lesions (SIL), the putative precursor to anal cancer. Since 2006, the Thai Red Cross AIDS ...

The Anal Cancer/High-grade squamous intraepithelial lesions Outcomes Research (ANCHOR) trial demonstrated that treating precancerous anal HSIL reduces the incidence of anal cancer by 57% in people ...

Source Reference: Fonseca BO, et al "Topical imiquimod for the treatment of high-grade squamous intraepithelial lesions of the cervix: a randomized controlled trial" Obstet Gynecol 2021; DOI: 10. ...

Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer. New England Journal of Medicine, 2022; 386 (24): 2273 DOI: 10.1056/NEJMoa2201048 ...

Sunil Badve, and Sulma I. Mohammed Mammary intraepithelial lesions (IELs) are nowadays frequently diagnosed as a result of the success of mammographic screening, education programs, and awareness by ...

Imiquimod cream is a safe, effective, first-line alternative to surgery for the treatment of vulvar high-grade squamous intraepithelial lesions (vHSILs), suggest the results from the first ...

The clearance rate of high-risk HPV16 and/or HPV18 was 31.4% vs 15.4% for the APL-1702 and placebo group, respectively.