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Study reveals immune-modulatory mechanism of lurbinectedin in small-cell lung cancer
Published this week in Cell Reports Medicine, the study reveals that the drug lurbinectedin, an approved second-line therapy for SCLC, activates the STING-IFN signaling pathway to enhance the ...
EurekAlert!9mon
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). (IMAGE)
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...
EurekAlert!11mon
cGAS-STING pathway response model for micronucleus (IMAGE)
An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...
BioWorld5d
ZNFX1 identified as a tumor suppressor in ovarian cancer
Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...
Medscape9d
IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity.
This research aims to explore the relationship between IL-33/ST2 and stimulator of interferon (IFN) response cGAMP interactor 1 (STING)-mediated signal transduction. METHODS: C57BL/6N mice (WT ...