There are five Rune types that can be slotted into an empty socket: Lesser Runes, Normal Runes, Greater Runes, Soul Cores, and Talismans. Like Soul Cores, Talismans have a special requirement that ...

and there are even talismans to increase damage for certain weapon types. Some talismans in the game, like Marika’s Scarseal, increase stats and the amount of damage you take from enemy attacks ...