The Republican-led Senate on Thursday overturned several key Biden-era waivers allowing California to set its own vehicle emissions, a major blow to that state’s effort to regulate pollution from cars and trucks that could have broad environmental impacts for the rest of the country.

The Senate has overruled the guidance of the parliamentarian, a nonpartisan staffer who interprets the Senate's rules, and voted 51 to 44 to overturn a waiver allowing California to set its own air po...

The winding series of Senate procedural votes that went late into the evening could have profound implications for California’s longstanding efforts to reduce air pollution.