Tigres dispatched reigning MLS champions LA Galaxy in the quarterfinals whilst, Cruz Azul bested bitter rivals Club América to reach the semifinals. Having left behind two of the region's most dangerous teams, Tigres and Cruz Azul have well-earned their spot amongst the final four of the competition.

Lionel Messi and Inter Miami will face the Vancouver Whitecaps, while Tigres UANL and Cruz Azul will meet in the Concacaf Champions Cup semifinals.