Piriformis syndrome is a rare neuromuscular condition that happens when the piriformis muscle in the butt presses on the sciatic nerve, according to the Genetic and Rare Diseases Information Center (GARD).

"It's a muscle that kind of clamps down on my sciatic nerve, and it was shooting down my leg," the actress said during an appearance on 'The Drew Barrymore Show'

Andie MacDowell has revealed she's been battling a painful muscle condition called Piriformis syndrome but she's been working with a personal trainer to find a "miracle" treatment.