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Introduction: Cxcl10 chemokine signaling has been implicated in cancer cell invasion and metastasis, but the mechanism is not well understood. Our prior studies have shown that deletion of the ING4 ...

Major Finding: Serotonin transporter depletes intratumoral serotonin which dampens CD8 + T-cell antitumor immunity. Concept: Serotonin transporter inhibition with SSRIs drives T-cell antitumor ...

In a letter addressed to NIH director Jay Bhattacharya, MD, dubbed the Bethesda Declaration, NIH staff members criticized many of the agency’s actions under the Trump administration. Representing all ...

Major Finding: PCSK9 regulates cholesterol uptake and controls the trajectory of metastasis to secondary organs in pancreatic ductal adenocarcinoma (PDAC). Concept: Cholesterol uptake supports ...

Cancer Res (2023) 83 (8_Supplement): LB320. QTX3034 has good solubility, permeability, and moderate protein binding in human plasma. The systemic clearance in rats and dogs was moderate to high, ...

SYNC-T, an investigational approach combining in situ vaccination, via partial tumor cryolysis, with intratumoral delivery of a cocktail of four immunotherapy agents, appears highly effective in ...

This first-in-human, phase I study evaluated ASTX660, an oral, small-molecule antagonist of cellular/X-linked inhibitors of apoptosis proteins in patients with advanced solid tumors or lymphoma.

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...

Publishing in July 2025 to coincide with the AACR Special Conference in Cancer Research: Artificial Intelligence and Machine Learning, the series will continue through December 2025! Technological ...