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1Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon. 2Division of Hematology/Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon. ...

1Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts. 2Massachusetts Eye and Ear, Boston, Massachusetts.

Major Finding: Iron activation within the lysosome triggers oxidative membrane lipid degradation and ferroptosis. Concept: Fentomycin-1 induces phospholipid oxidation and ferroptosis in cancer cells ...

Cancer Res (2024) 84 (6_Supplement): 2583. Introduction & Purpose: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. To date, the imaging of HCC is difficult, insufficient for ...

Inavolisib (Itovebi; Genentech) boosted survival in patients with HR-positive, HER2-negative advanced breast cancer and extended the time they could wait before starting chemotherapy. In the phase III ...

Bristol Myers Squibb (Princeton, NJ), Princeton, NJ.

Genentech will collaborate with Orionis Biosciences to discover and develop molecular glues for cancer, the companies announced today. Molecular glues are small molecules that bind to, and promote ...

Findings from a multinational study suggest that adding an AI-integrated platform to training masterclasses for pathologists boosts their accuracy in classifying HER2-stained breast cancer samples, ...

Researchers found a treatable mechanism behind the cognitive problems that can follow CAR T-cell therapy, tracing them to overactive immune cells in the brain’s white matter. In mouse models, ...

Treatment with lurbinectedin (Zepzelca; Jazz Pharmaceuticals) and atezolizumab (Tecentriq; Genentech) improved overall survival (OS) in patients with extensive-stage small cell lung cancer (ES-SCLC) ...

Major Finding: An inflammatory signature is a prognostic biomarker for CAR T-cell failure in non-Hodgkin lymphoma. Concept: InflaMix uses results from common blood tests to predict survival and ...