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Gut13d
Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression
Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of ...
gut.bmj7h
O33 Health call-a novel system to improve patient pre-assessment
Introduction Newcastle upon Tyne NHS Foundation Trust Endoscopy Pre-Assessment is a high volume service currently pre-assesing 900 patients per month. A large waiting list for procedures bulit up as a ...
gut.bmj4d
Perspective on enhancing CRC risk prediction
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gut.bmj11d
Response to: correspondence on 'Revisiting the role of sphincterotomy in sphincter of Oddi disorder: a critical appraisal of the RESPOnD study by Zeng
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gut.bmj1d
Guidelines for the management of iron deficiency anaemia
Correspondence to Brian B Scott, Department of Medicine, Lincoln County Hospital, Lincoln LN2 5QY, UK; drbbscott{at}aol.com Iron deficiency anaemia (IDA) occurs in 2–5% of adult men and postmenopausal ...
gut.bmj9d
Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and ...
gut.bmj5d
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...
gut.bmj4d
Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts
Objective We aimed to determine the predictive capacity and diagnostic yield of a 10-fold increase in serum IgA antitissue transglutaminase (tTG) antibody levels for detecting small intestinal injury ...
gut.bmj4d
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma
Objective To characterise gut microbiome in patients with hepatocellular carcinoma (HCC) and evaluate the potential of microbiome as non-invasive biomarkers for HCC. Design We collected 486 faecal ...
gut.bmj9d
TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality
Background PARP inhibitors (PARPi) have been licensed for the maintenance therapy of patients with metastatic pancreatic cancer carrying pathogenic germline BRCA1/2 mutations. However, mutations in ...
gut.bmj9d
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Correspondence to Professor Alfred Sze-Lok Cheng, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; alfredcheng{at}cuhk.edu.hk; Professor Joseph Jao-Yiu Sung, Lee ...
gut.bmj5d
Safely restarting GI endoscopy in the era of COVID-19
Correspondence to Dr Bu"Hussain Hayee, King"s Health Partners Institute for Therapeutic Endoscopy, King"s College Hospital, London SE5 9RS, UK; b.hayee{at}nhs.net The COVID-19 pandemic has placed ...