A new paper argues that the popular allergy medication is a worse choice than newer drugs, like Claritin and Allegra. Experts ...

This risk was even higher in children aged 6 to 24 months who were prescribed first-generation antihistamines (aOR, 1.49) versus children aged 25 months to 6 years (aOR, 1.11).

A Korean study identified a 22% increased risk for seizure among young children who were prescribed first-generation antihistamines, according to findings published in JAMA Network Open ...

A first generation antihistamine, called cinnarizine, is known to improve blood flow to the inner ear, which can reduce feelings of nausea and dizziness caused by travel sickness.

Stratified analyses showed similar results, especially among children six months to two years of age who received first-generation antihistamine prescriptions having a risk of seizure (AOR, 1.5 ...

Older antihistamines, known as first-generation antihistamines, such as diphenhydramine (ZzzQuil) and doxylamine (Unisom) cross into the brain and block histamine receptors there, whereas second ...

The first-generation antihistamines specifically target a key brain chemical involved in memory that is called acetylcholine. Because of their design, they have a long-term impact on our brain’s ...

About The Study: Prescriptions for first-generation antihistamines were associated with a 22.0% higher seizure risk in children, especially in those ages 6 to 24 months in this cohort study.

Second-generation antihistamines are also less likely to make you drowsy, a major complaint with first-generation antihistamines. “Allergists often recommend these over first-generation antihistamines ...

TOPLINE: First-generation antihistamines are linked to a 22% higher risk for seizures in children, new research shows. The risk appears to be most pronounced in children aged 6-24 months.

Importantly, the use of first-generation antihistamines such as chlorpheniramine (Chlor-Trimeton), dimenhydrinate (Dramamine), cyproheptadine (Periactin), tripelennamine (Pyribenzamine ...