Symptoms: Symptoms of acromegaly usually begin sometime after puberty, most commonly between the ages of 40 and 50. The disease causes a person's bones to enlarge — most notably, in the hands ...

with noncured acromegaly. Serum IGF-I and GH levels were measured by validated assays. In total, 81 patients had active disease (IGF-I and GH both high), 68 patients had biochemically controlled ...