An example of the repair of articular cartilage defects by use of a hydrogel seeded with MSCs is presented, to highlight the current strategies, limitations and perspectives of using MSCs to treat OA.

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

articular cartilage is populated by mechanosensitive cells (chondrocytes), which signal via highly analogous pathways. Alfredson and Lorentzon treated 57 consecutive patients with isolated ...

Lindsey DeSoto, RD, is a nutrition writer, medical reviewer, and registered dietitian who helps clients improve their diet for health-related reasons. Her writing covers a variety of topics ...

Full-thickness osteochondral defects penetrate the entire thickness of articular cartilage to the subchondral bone. Unlike partial-thickness defects, full-thickness defects are accessible to MSCs, ...

Injuries to the articular cartilage in different joints, including the knee, are painful and limit mobility. In response, researchers at the University of Basel and University Hospital Basel are ...

Scientists at Queen Mary University of London have invented a new way to repair osteochondral defects – a common form of ...

In ACLR and uninjured contralateral knees, the patella articulates higher on the femoral trochlea due primarily to a longer patellar tendon compared with healthy knees.

Reform UK leader Nigel Farage has welcomed 29 councillors who have defected to his party in recent weeks from parties including the Conservatives and the Liberal Democrats. It takes the party's ...