Callie goes through a lot on the show, from marrying and divorcing George to realizing she's bisexual to getting pregnant by Mark Sloan. She has definitely had her fair share of drama.

Callie became irritated at always coming after Izzie and Meredith. She broke it off with George, and that same evening, had a one-night-stand with Mark Sloane.

Rhimes ponders of season 10. “Callie isn’t a victim; she’s never really been a victim, and she’s been cheated on before with George.