We should be vigilant of symptoms of anal squamous intraepithelial lesions (pre-cancerous lesions), such as pruritus, bleeding, discharge, irritation, and tenesmus.

A new research paper was published in Oncotarget, Volume 16, on April 24, 2025, titled "PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region." ...

Human papillomavirus (HPV) prevalence by lesion type In total, 76 studies presented HPV prevalence by single lesion types, of which 38 provided any-HPV prevalence and 65 HR-HPV prevalence. The any-HPV ...

The Anal Cancer/High-grade squamous intraepithelial lesions Outcomes Research (ANCHOR) trial demonstrated that treating precancerous anal HSIL reduces the incidence of anal cancer by 57% in people ...

A new HPV vaccine induced regression of precancerous cervical lesions in 50% of patients and led to viral clearance in some patients.

An investigational therapeutic vaccine showed clinical effectiveness in patients with human papillomavirus (HPV)16-positive cervical intraepithelial neoplasia grade 3 (CIN3), according to results ...

Accounting for approximately 350,000 deaths annually worldwide, cervical cancer is preventable with HPV vaccination and screening. Newer chemotherapy, radiotherapy, and immunotherapy techniques hav ...

R87610 Atypical squamous cells of undetermined significance on cytologic smear of cervix (ASC-US) R87611 Atypical squamous cells cannot exclude high grade squamous intraepithelial lesion on ...

As of the date of this publication, APL-1702 has not been approved for the treatment of cervical high-grade squamous intraepithelial lesions (HSIL); APL-1706 has not been approved for the diagnosis or ...