With the participation of U5, the 3′ end of the intron is brought into proximity ... attacks the phosphodiester bond at the 3′ splice site. The adjoining exons are covalently bound, and ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning ...

It is absolutely vital that the splicing complex accurately recognizes exon-intron-exon junctions so the ... mRNA with a non-authentic splice site,” explains Prof. Hurt. In studies with ...