Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Analyses comprise evolutionary conservation, splice-site changes, loss of protein features ... than 12 base pairs and alterations spanning an intron-exon border. Also, analysis of non-exonic ...

Matched rate and Length distributions distributions of different intron optimal ... introns after splicing could be related to NMD. The matched frequencies bounded by functional sites in the sequences ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

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To date, variants in genes involved in transcription regulation, chromatin remodelling, α-dystroglycan glycosylation, cytoskeleton and scaffolding protein, RNA splicing, and the MAP kinase signalling ...

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