Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control ...

It is absolutely vital that the splicing complex accurately recognizes exon-intron-exon junctions so the ... mRNA with a non-authentic splice site,” explains Prof. Hurt. In studies with ...

Analyses comprise evolutionary conservation, splice-site changes, loss of protein features ... than 12 base pairs and alterations spanning an intron-exon border. Also, analysis of non-exonic ...

Matched rate and Length distributions distributions of different intron optimal ... introns after splicing could be related to NMD. The matched frequencies bounded by functional sites in the sequences ...

Surprisingly, we found RBM20, an alternative splicing regulator associated with dilated cardiomyopathy ... Correlation of differential gene expression in Rbm20 ΔVglut2 cells, intron length and ...