The aircraft was on a sightseeing flight when it suddenly broke apart in midair, its rotor blades falling separately toward the water. By Patrick McGeehan When rescue crews reached the passenger ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...

the researchers obtained the structure of the U11 snRNP complex and revealed how it recognises the "5' splice site" -- the starting point of an intron -- to initiate the editing process at this ...

the researchers obtained the structure of the U11 snRNP complex and revealed how it recognises the "5' splice site" – the starting point of an intron – to initiate the editing process at this ...

Mol. Cell, 2018; Nat Commun 2021). Splicing modulators that bind SF3B1 act as competitive antagonists of the branch site, in a manner dependent on the intron’s sequence (Cretu et al., Mol. Cell, 2018; ...

Introners copy and paste themselves into stretches of coding DNA that offer an appropriate splicing site. Then they move on, leaving behind a specific intron sequence flanked by splicing sites, which ...

Clinical Nomogram Using Novel Computed Tomography–Based Radiomics Predicts Survival in Patients With Non–Small-Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Colorectal cancer (CRC) ...

The relationship between intron-retention–derived tumor neoantigens (IR-neoAg ... and more common than alternative 5′- and 3′-splice site and mutually exclusive exons (13.7%, 12.1%, and 0.7%, ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor Protein-coding genes carry the blueprint for protein production. In higher ...

The Effect of Intron −3C Substitutions at the 3′ Splice Site The bootstrap difference analysis below shows that the 3′ intron end substitutions of the conserved −3C are supported by the increase in U5 ...

This mutation involves the deletion of an adenine in intron 11 that abolishes the canonical splice acceptor site of exon 12 (Perrone et al., 2018). This leads to exon 12 skipping and a frameshift ...