Such an ideal pre-mRNA contains good splicing signal sequences, i.e., the 5′ splice site, the branch-site (BS) sequence, and the polypyrimidine tract (PPT) followed by the 3′ splice site that ...

Structural basis of 5′ splice site recognition by the minor spliceosome. Molecular Cell, 2025; 85 (3): 652 DOI: 10.1016/j.molcel.2024.12.017 ...

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.

If I trained a model to predict a good intron [using] data that is already in nature, we wouldn’t get good rules,” she explained. That meant that “we had to make the data ourselves.” ...