A new lab-grown material has revealed that some of the effects of aging in the heart may be slowed and even reversed. The ...

Before considering specific inhibitors of cardiac hypertrophy, it is worth summarizing what one is trying to reverse. The heart is composed of multiple cell types, including muscle cells ...

Some of these supplement names are getting out of hand. Protein powder? Easy to understand. Creatine? A little tougher, but ...

For over a decade, scientists have been growing organoids—small clusters of cells that mimic a particular organ—to serve as ...

The regulation of these cardiac metabolic pathways has been ... heterozygous deletion or conditional deletion in heart and muscle reduces mtDNA copy number, impaired transcription of ...

Thus, establishment of the mitochondrial system and engagement of oxidative metabolism are prerequisites for the differentiation of stem cells into a functional cardiac phenotype. Mitochondria ...

Edited by Janet Rossant, The Gairdner Foundation, Toronto, ON, Canada, and approved February 19, 2021 (received for review October 8, 2020) Adult mouse muscle satellite cells (MuSCs) are quiescent in ...

BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

People often refer to mitochondria as the powerhouses of the cell. Their main function is to generate the energy necessary to power cells, but they are also involved in cell signaling and death.

*NHLBI, NIH, 10 Center Dr., Room B1D416, Bethesda, MD 20892. E-mail: [email protected]. Phone: (301) 496-2679. Fax: (301) 402-2389. Article Views are the COUNTER-compliant sum of full text article ...

I always wanted to understand life. What moves us? What allows us to heal and thrive? And what goes wrong when we get sick or when we eventually stop breathing and die? My search for answers to ...

In biology classes from high school through university, I learned that mitochondria are little objects that reside within each cell and serve ... We were imaging muscle from the calf of a woman ...