Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to ...

Find out what happens to heart cells in space and how their adaptation could revolutionize heart disease treatment.

We differentiated induced pluripotent stem cells from risk, nonrisk donors at 9p21.3, and isogenic knockouts into vascular smooth muscle cells (VSMCs). We performed single-cell transcriptomic ...

The results show that mitochondria, which generate the energy that powers cells, differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions ...

Skeletal muscle ... induced cell death is involved in SAW remains unclear. In this paper, we review the possible relationship between cuproptosis and SAW. Cuproptosis may be involved in regulating the ...

6 Powered by actin polymerisation, these tubes can punch their way from the heart muscle cells through the tangle of collagen and other fibrous proteins called cardiac jelly, so that the two cell ...

Skeletal muscle atrophy and the ... and regenerating muscle stem cells plays a crucial role in regulating Notch signaling through the interaction of MAM. Our research demonstrates that the restoration ...

We also suggest that the MitomiR-dependent control could be further enhanced through the transfer of mitochondria from donor to target cells, as a new strategy for MitomiR delivery. Mitochondria as ...

View Full Profile. Learn about our Editorial Policies. The paper C. Fecher et al., “Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity,” Nat Neurosci, ...