A Miami jury ordered Elon Musk’s car company on Friday to pay $329 million to victims of a deadly crash involving its Autopilot driver assist technology, opening the door to other costly lawsuits and striking a blow to Tesla’s reputation for safety.

Tesla Inc. was told to pay $243 million in a lawsuit over a 2019 Autopilot crash in Florida that killed a young woman and seriously injured her boyfriend, the first significant court loss for the automaker in litigation related to its driver-assistance technology.