The ratios of drug AUC in the peritoneal cavity and AUC in systemic blood are 12 for cisplatin, 10 for carboplatin, 65 for melphalan, 65 for etoposide, 75 for mitomycin C, 367 for 5-fluorouracil ...

The area under the busulfan concentration vs time curve (AUC) was calculated using the following equation: AUC = 45C 1h + 15C 1.5h + 270C 1.5h / (ln C 1.5h − ln C 6h) where C 1h, C 1.5h and C 6h ...

Furthermore, we determined that the variable of CRP > 62.8 mg/L did not increase the prediction performance of the APACHE II score using the AUC-ROC comparison by the DeLong method.

Both initial vancomycin trough values and 0-24-h at steady state AUC values were associated with nephrotoxicity in the bivariate analyses. However, the vancomycin trough value, modeled as a continuous ...