and use similar actin- and myosin-mediated protrusions and guidance by extrinsic chemotactic and mechanical cues as used by single migratory cells. However, cadherin-based junctions between cells ...

In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is commonly known to be responsible for protein trafficking and secretion. In ...

Primary antibodies were used at a 1:200 dilution: p-Y-576/p-Y-577–FAK (focal adhesion kinase) (Cell Signaling, Boston, MA); FAK, actin, PECAM-1, β-catenin (Santa Cruz, Santa Cruz, CA ...

Mechanistically, IL-1β activates RhoA/ROCK signaling through a non-canonical IL-1 receptor-dependent pathway, which drives the enrichment of actin bundles at the cell-cell junctions, thus prevents ...

By visualizing a RhoA biosensor and actin, they found a redistribution of RhoA to the cell periphery and cell-cell junctions after IL-1 stimulation. This triggered the formation of actin bundles at ...

Methods: The effect of gliadin on the enterocyte actin cytoskeleton was ... release in intestinal epithelial cells in vitro. Activation of the zonulin pathway by PKC mediated cytoskeleton ...

Each muscle fiber consists of a cross-banded structure that is further divided into myofibrils that contain thick (myosin) and thin (actin) myofilaments ... at the neuromuscular junction, the space ...

Rhobo6, a light microscopy probe, gives scientists an unprecedented look at the extracellular matrix -- the collection of organized molecular structures that fills the spaces between cells in our ...

New research reveals that brain cells use a muscle-like signaling mechanism to relay information over long distances.

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste. This process, known as autophagy, is like a self ...

In 2009 a team of biophysicists led by Anthony A. Hyman of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, were studying specklelike structures called P ...