In reverse splicing, the free spliced group I intron inserts itself into another RNAs through base complementarity of 4-6 nucleotides between the intron and the RNA exon (Hedberg and Johansen, 2013), ...

Nearly 50 people have been reported killed and 300 others wounded in incidents near the Israeli-backed distribution center, which was designed to keep food out of the hands of Hamas.

Cancer of unknown primary site is an ever-evolving disease entity and one of the most challenging diagnoses to manage in oncology. 1-3 The term “cancer of unknown primary site” encompasses a ...

The Role of the Spliceosome Splicing is catalyzed by a large molecular machine. This spliceosome is made up of variety of protein and RNA components, and for each splicing process, it is reassembled ...

"Our work provides exciting new insights into the mechanism of minor intron recognition and sheds light on the evolution of the splicing machinery.

Boehringer will leverage ExpressionEdits' Genetic Syntax Engine which generates optimized introns to increase protein expression.

However, delineating between intron retention and other forms of alternative splicing (i.e., cryptic splice site recognition) requires a more comprehensive consideration of the intron splicing defects ...

The authors show that after the spliceosome is finished splicing the mRNA, it remains active and can engage in further reactions with the removed introns. This discovery provides the strongest ...

Defects in RNA processing can promote cancer -- but the mutated proteins responsible can be hard to target. Fred Hutch Cancer Center and Memorial Sloan Kettering Cancer Center scientists discovered a ...