The absence of Matthijs de Ligt continues, his foot injury lingering like a bad subplot. Lisandro Martinez, Ayden Heaven, and Jonny Evans are all out. In response, Harry Maguire is expected to partner the increasingly composed Leny Yoro, who’s looked like the one adult left in the room.

Joshua Zirkzee and Mason Mount could be brought in to freshen up the United attack, while Kobbie Mainoo returned to the squad for Thursday's first leg with Lyon. Andre Onana will remain in goal despite two more costly errors against Lyon, as United drew 2-2.