A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing Factor ...

Researchers at the University of Cologne have identified the key mitochondrial protein AIFM1 as a central coordinator of ...

14 Mar 2025. A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, ...

Mitochondrial DNA (mtDNA) quantification is crucial in understanding mitochondrial dysfunction, which is linked to a variety of diseases, including cancer and neurodegenerative disorders. Traditional ...

Cryo-EM shows the full-length human mitochondrial RNase Z complex in various maturation states of mitochondrial tRNA. The structure explains substrate recognition and catalysis, the 5′-to-3′ ...

We used a correlative light and EM dataset (Scholl et al., 2021) to characterize mitochondria within basal dendrites of L2/3 pyramidal neurons of the ferret V1 and relate their abundance near spines ...

How a cell's mitochondria make their own protein factories. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2022 / 12 / 221208114829.htm ...

The mitochondrial ribosome, or mitoribosome, ... “Cryo-EM allowed us to identify and isolate individual stages of the assembly pathway from a heterogeneous population of purified complexes, and we are ...

The mitochondrial impairment could also be indicated via reduced expression of mitochondria-related genes from the mitochondrial metabolic pathway. To further investigate the potential relevance of ...

In PNAS, using cutting-edge cellular cryo-EM (Fig. 1A), Leung et al. report structural diversity and conservation of mammalian sperm mitochondria in greater detail. Sperm mitochondria are tethered to ...

Delineation of mitochondria from electron microscopy (EM) images is crucial to investigate its morphology and distribution, which are directly linked to neural dysfunction. However, it is a ...