The pathophysiology of heart failure is complex, but mitochondrial dysfunction is an emerging therapeutic target to improve cardiac function. In this Consensus Statement, insights into the ...

A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing Factor ...

A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing ...

Researchers at the University of Cologne have identified the key mitochondrial protein AIFM1 as a central coordinator of ...

Mitochondrial content in endothelial cells is modest compared with other cell types with higher energy requirements. In the rat, for example, mitochondria occupy 2% to 6% of cytoplasmic volume in ...

The mitochondrial proteome is a genetic mosaic of nuclear and mitochondrially encoded proteins (Morgenstern et al, 2017; Rath et al, 2021).The mitochondrial genome is tiny and encodes only for a small ...

“We observed a significant loss of the mitochondrial protein COXIV in demyelinated Purkinje cells, suggesting that mitochondrial impairment contributes directly to cell death and cerebellar damage.” ...

Mitochondria play vital roles not only as cellular energy factories but also as the main organelles to produce intracellular ROS and maintain the balance of oxidation stress and inflammation. Thus, ...

This correlated with elongated ER-mitochondria contacts as observed by electron microscopy (EM). Evaluation of MAM function and ER-mitochondria communication further demonstrated an upregulation of ...

Mitochondria-Targeting Biquaternary Ammonium Compounds: Pancreatic Anticancer Activity and Synergistic Interaction with Metformin. ... Fluorescence intensity was measured using a microplate reader at ...