X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

Genetic studies in patients with apparent sporadic Paget disease are difficult to interpret because this disorder is often asymptomatic. Bone scans of a patient's parents are required to rule out ...

Use precise geolocation data and actively scan device characteristics for identification. This is done to store and access ...

In other groups, it’s less common. Paget's disease is diagnosed based on a person’s signs and symptoms, an X-ray, and an imaging test that uses a tracer to look for bone damage or disease (bone scan).

If the disease progresses, it causes new bone development. As a result, vertebrae can fuse together. 6. Paget's Disease of Bone Paget’s is a chronic bone disorder that causes rapid and excessive ...

In an exclusive interview with PEOPLE, Jay and Pamela — both born with osteogenesis imperfecta, or brittle bone disease — open up about keeping a positive mindset despite challenges. They are starring ...

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel ...

In patients with chronic kidney disease (CKD), renal retention may impact total PINP and β-CTX-I levels, necessitating alternative markers such as bone alkaline phosphatase (BALP), intact PINP and ...

It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age ...