Juvenile Paget disease (JPD) is a very rare disease, mainly caused by biallelic inactivating mutations in the TNFRSF11B gene that encodes osteoprotegerin. Owing to its rarity, the treatment of JPD is ...

More than one million people will receive between £29.20 and £187.45 each week over the new financial year through PIP or Adult Disability Payment for musculoskeletal conditions.

Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

Emma Appleton, Lady Clara Paget and Lady Amelia Windsor enjoyed a night on the tiles as they celebrated the opening of new London restaurant ALBA. The new Italian restaurant in Knightsbridge ...

The pair were both born with osteogenesis imperfecta type 3 — often called brittle bone disease. The rare genetic bone disorder makes people more susceptible to breaking and fracturing bones and ...

Why People Get Bone Marrow Transplants Bone marrow transplants are often used to treat serious diseases and cancers that affect bone marrow function. The transplant aims to replace diseased or ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...

To commemorate World Cancer Day, we've put together everything you need to know about bone cancer – and how to look spot the symptoms.

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Purpose: We investigated the bone mineral status in patients with untreated Fabry disease (FD). Methods: Descriptive, cross-sectional study in 53 patients with FD investigating bone mineral ...