eLife15d
The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells
Prostaglandin E2 (PGE2) is an endogenous inhibitor of glucose-stimulated insulin secretion (GSIS) and plays an important role in pancreatic β-cell dysfunction in type 2 diabetes mellitus (T2DM). This ...
Dot Esports17d
CS2’s release date: When did CS2 first release?
27, it definitely felt like Valve forced the issue with the launch. This part of Counter-Strike 2’s release history must not be forgotten, but from the perspective of 2025, most if not all of ...
TechRadar25d
Nintendo Switch 2: what we know about the next-generation system so far
Some eight years since the Nintendo Switch was released, we have finally got an official look at the Nintendo Switch 2. In a rather brief trailer, Nintendo showed off its next-generation gaming ...
Frontiers1y
Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Klebsiella pneumoniae, first described by Carl Friedlander in 1882, is a capsulated, anaerobic facultative, and rod-shaped gram-negative bacterium. This pathogen is found ubiquitously in nature, ...
eLife3y
Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut
The accumulation of antibiotic resistance genes in pathogenic bacterial strains is an important cause of antibiotic treatment failure. Conjugative antibiotic resistance plasmids are key drivers of ...