DNA is fundamental to the biology of all life on Earth, but how many of us actually know what it is or what it's made of?

Purine nucleotides are considered to be the only inhibitors of UCP1 activity, binding to its central cavity to lock UCP1 in a proton-impermeable conformation. Here we show that pyrimidine nucleotides ...

Synopsis Short-circuitry of brown adipose mitochondria by proton leak through activated human uncoupling protein (UCP1) leads to heat production and this process is thought to be inhibited ...

Cluster of differentiation 73 (CD73) converts adenosine 5′-monophosphate to immunosuppressive adenosine, and its inhibition was proposed as a new strategy for cancer treatment. We synthesized ...

Certain types of alcohol, like beer, have higher purine content and can accelerate the breakdown of nucleotides, another source of purines that are converted into uric acid.

Credit: Kateryna Kon/Science Photo Library/ What is DNA, and how does it work? You don't need a degree in genetics to understand. Here, we'll give an overview of DNA and answer questions ...

IN earlier papers 1,2 we have reported studies on the changes in acid-soluble nucleotides of carp muscle in which they found the accumulation of inosinic acid as a result of slow freezing. Further ...

Xanthine oxidase is an essential enzyme within the uric acid metabolic pathway and is required for the breakdown of purine nucleotides.

ABSTRACT: Purine nucleotides are crucial for the effective operation of cell membrane proteins maintaining the neurotransmitter responses of 5-HT. Major protein targets in the treatment of depression ...

It is a normal part of metabolic breakdown of purine nucleotides and a normal component of urine. High rates of UA or build-up increases the risk of some health problems (such as gout and ...

Methods of Nucleoside Bond Formation Summary Nucleic acid is a biopolymer compound composed of nucleotides and is one of life’s basic substances. It is widely found in all animal and plant cells, ...