The scientists show how purines and pyrimidines can form from a common precursor molecule that could have existed before life on Earth began. They find 8-oxo-purine shares underlying similarities ...

Purines are heterocyclic bases. Simply put, these are closed ring structures comprised of at least two different kinds of atoms. Purines are one of three components of nucleotides; phosphate ...

DNA is fundamental to the biology of all life on Earth, but how many of us actually know what it is or what it's made of?

Purine nucleotides, such as ATP and GTP, serve as energy carriers and regulators of cellular functions. ATP (Adenosine Triphosphate) ATP is the primary energy currency in cells. It consists of an ...

Since dietary nucleotides are a potential source of purines for the salvage pathway, Hoxhaj’s team wondered whether supplementing mice with nucleotides could impact tumor growth. They fed ...

Xanthine oxidase is an essential enzyme within the uric acid metabolic pathway and is required for the breakdown of purine nucleotides. The breakdown products of XO, including uric acid (“UA ...

XORTX Highlights Pioneering Research Indicating a Role for Genetic Regulation of Xanthine Oxidase and Therapeutic Targeting of Aberrant Purine Metabolism PRESS RELEASE GlobeNewswire Aug. 29, 2024 ...