Autophagy is an intracellular process that targets various cargos for degradation, including members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double-stranded DNA and triggers ...

Here, our data demonstrated that ASFV structural protein p17 exerts a negative regulatory effect on cGAS-STING signaling pathway and the STING signaling dependent anti-HSV1 and anti-VSV functions.

Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...

TDP43 seems to worsen the inflammatory activation of astrocytes in neuromyelitis optica spectrum disorder (NMOSD), a study found.

We used Toll-like receptor-specific reporter cells and reporter cells harbouring knockouts of cGAS, STING and IFNAR2 to evaluate signalling pathway-dependent ISG induction. Results IFN-I bioactivity ...

Dry January is mostly pain and not so much gain, says our writer. It’s month two and three that you really start to enjoy the ...

MSI subtype additionally showed prominent structural damage and dysfunction of mitochondria, which resulted in downregulation of ATP-dependent pathways, and activation of cGAS-STING signaling. However ...

It would sting a little when people forgot that it was hard for me ... According to PRT practitioners, the primary cause of neuroplastic pain is changes in neural pathways; a person might have ...

This research aims to explore the relationship between IL-33/ST2 and stimulator of interferon (IFN) response cGAMP interactor 1 (STING)-mediated signal transduction. METHODS: C57BL/6N mice (WT ...

View Full Profile. Learn about our Editorial Policies. When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team wanted to identify ...

Sting has canceled an upcoming appearance and postponed three shows amid an ongoing illness. “On advisement from his doctor, due to illness, it is with sincere regret that Sting must cancel his ...