Tegaserod -- a selective 5-HT 4 partial agonist -- recently was approved in the U.S. for treating the constipated variant of irritable bowel syndrome (IBS). However, the safety of IBS treatments ...

This article examines post-market drug safety, highlighting surveillance mechanisms, regulatory responses, and case studies of approved drugs with hidden risks.

He reported that he discusses the unlabeled uses of the FDA-approved products tegaserod and sildenafil.

The human gastrointestinal tract harbors most of the microbial cells inhabiting the body, collectively known as the microbiota. These microbes have several implications for the maintenance of ...

Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to the ...

Objective Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and ...