Manchester United have won 16 of their last 18 home FA Cup matches (D2), although one of those draws saw them eliminated on penalties by Middlesbrough in February 2022. The last visiting side to win in normal time at Old Trafford were Arsenal in March 2015, a 2-1 victory.

It's an Old Trafford return for Ruud Van Nistelrooy with Leicester City after the former Manchester United player was the caretaker of the Red Devils prior to Ruben Amorim's appointment. While both are now managing in the Premier League,