His appearance headlined a jam-packed episode of SmackDown on USA Network, which also featured the 2025 Andre the Giant Memorial Battle Royal, The Street Profits defending the WWE Tag Team Championship, and all of the final hype for the biggest show of the year.

SmackDown took place Friday, the final show before WrestleMania 41, offering stars competing in the spectacle one last chance to make a statement before the wrestling world turns its attention to Allegiant Stadium on Saturday, April 19 and Sunday, April 20.

Rey Mysterio is scheduled to face El Grande Americano Saturday night at WrestleMania 41, but that match may now be in question. The WWE Hall of Famer was competing in a six-man tag team match Friday night on SmackDown and suffered an injury at some point during the bout.